The time interval of somitogenesis and the length of somite under various temperatures in zebrafish
08/7/22, 13:30 at Room 3631 (6th floor of building 3 of the Faculty of Sciences)
Vertebra, axial muscles and other segmental structures are developed from somites in vertebrate. Embryos might keep the length of each somite constant under various environmental conditions for normal development. In this talk, I introduce an experimental study focusing on the time interval of somitogenesis (the time interval between the formation of one unit and the next) and on the length of each somite under various temperatures in zebrafish (Schroer et al. 2008, Dynamics of zebrafish somitogenesis. Dev. Dyn. 237. 545-553). The study shows that the time interval of somitogenesis becomes shorter as the temperature increases. The study also shows that the length of each somite is constant under various temperatures. The time interval of somitogenesis is considered to be determined by the period of oscillatory expression of segmentation clock genes and the length of somite is considered to be determined by the moving distance of the wavefront (a threshold of Fgf concentration for cell differentiation) during one cycle of clock gene expression. Therefore the result of this study suggests that the wavefront velocity changes by the temperature to keep the length of each somite constant. We confirmed, by a mathematical model, that the period of oscillation of segmentation clock gene determines the time interval of somitogenesis and that the moving distance of the wavefront during one cycle of clock gene expression determines the length of somite. The result of the model supports the idea that the wavefront velocity changes by the temperature.
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