Stochastic modelling of cellular oscillators

Robert Schlicht
(Institute of Biomathematics and Biometry, Helmholtz Center Munich, Germany)

08/09/30, 13:30 at Room 3631 (6th floor of building 3 of the Faculty of Sciences)


Processes in molecular biology that generate oscillations often involve reactions with delays. In addition, if molecules appear in small numbers, these processes are subject to stochastic effects. I will first present a non-Markovian stochastic model that provides a precise mathematical description of these phenomena. The model can explain the oscillations that control segmentation in vertebrate embryos. It shows patterns that are clearly distinct from those in a corresponding deterministic model. In the second part of the talk I will discuss how to distinguish oscillation from mere noise, how to efficiently simulate discrete molecular processes with delays and how to integrate stochastic and deterministic approaches.


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