Three-dimensional cellular vertex model for epithelial morphogenesis
|
Every multicellular organism begins as a single cell and increases in complexity through cell proliferation, differentiation, and transformation. All these embryonic processes are types of morphogenesis which is the generation of form. Epithelia are various tissues composed of tightly connected cells which build tissue surfaces of the body. Epithelial morphogenesis is very important to understand shape of an organism in regards to developmental biology. This subject is difficult to study by reason of the intrinsic complexity of itself. Accordingly, computational modeling which solves a complicated problem using graphical and numerical tools is appropriate for analyzing epithelial morphogenesis. There are various approaches in computational modeling, including cell lattices, centric, cellular Potts, finite element and boundary vertex models. Most of these models are two-dimensional and we propose to improve the boundary vertex model which has the advantage of three-dimensional extension. Then we will build a new three-dimensional vertex model including the concept of the cellular structure and its application program using C++. |
| Back: Japanese / English |