Dynamics and efficacy of viral interference in HIV infection
Viral interference is a phenomenon by which a virus infected cell displays reduced susceptibility to infection by a virus of the same species. This phenomenon, also called superinfection resistance, is generally due to occupation or down-regulation of cellular proteins that are required for virus replication. In this respect, the principal mechanism of HIV superinfection resistance is down-modulation of the CD4 receptor from the cell surface. Recent data, however, strongly suggest that HIV superinfection resistance involves several CD4-independent mechanisms that remain to be fully understood.
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