Modeling ecliptic phase of SHIV infection in cell culture
The time between virus entry and the start of viral production (i.e., ecliptic phase) is widely distributed. However, so far, many mathematical models were constructed by ordinary differential equations (ODE) and implicitly assumed the ecliptic phase is distributed exponentially, although some mathematical models considered non-exponential distribution. This simplification of the ecliptic phase might miss several important features underlying virus infection dynamics. Therefore, multi-scale modeling which could include non-exponential distribution is important and recently has been receiving a lot of attention.
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