Mathematical Biology Laboratory Department of Biology, Kyushu University

Yusuke Ito

NAME

Yusuke Ito

Email: uks3tkwbft[at]gmail.com
Please convert [at] to @ when you send an email.

CURRENT POSITION

Doctorate course student, Graduate School of Systems Life Sciences, Kyushu University

EDUCATION

  • B.S. Kyushu University, Japan, 2016 (Biology)

RESEARCH INTERESTS

(Ⅰ) Modeling nonrandom HIV-1 co-infection in vitro

Human Immunodeficiency Virus type 1 (HIV-1) accumulates their mutants by both recombination and mutation during the course of the infection. HIV-1 recombination, as well as HIV-1 infection, is likely to be promoted more effectively by “co-infection” events. The co-infection of HIV-1 is defined that multiple viruses infect target cells simultaneously. Recently, it has been experimentally confirmed “nonrandom HIV-1 co-infection”, a phenomenon in which multiple viruses target cells in cell culture, occurs more frequently than it would be expected. One possible explanation for the nonrandomness is a heterogeneity of susceptibility of target cells, proposed by Q. Dang et al., 2004. In this study, we developed a novel mathematical model for “nonrandom HIV-1 co-infection” and quantitatively analyzed the datasets of co-infection experiments. First, we derived the stochastic model including the heterogeneity of susceptibility of cells. Interestingly, the model allows us to predict theoretically that nonrandom HIV-1 co-infection is more likely to happen under our assumptions, as previous works have suggested experimentally. In addition, as the results of quantitative analyses of experimental co-infection datasets using the model, we could estimate the number of viruses to invade target cells under the nonrandom co-infection cases. These information will be useful for further understanding not only the impact of co-infections on the frequency of HIV-1 recombination but also the diversity of HIV-1.

Shoya Iwanami

NAME

Shoya Iwanami

Email: iwanami.shoya.634[at]s.kyushu-u.ac.jp
Please convert [at] to @ when you send an email.

CURRENT POSITION

Doctorate course student, Graduate School of Systems Life Sciences, Kyushu University

EDUCATION

  • B.S. Kyushu University, Japan, 2016 (Biology)

RESEARCH INTERESTS

Hematopoietic stem cell

PUBLICATIONS

[1] S. Iwanami, Y. Kakizoe, S. Morita, T. Miura, S. Nakaoka and S. Iwami. A highly pathogenic simian/human immunodeficiency virus effectively produces infectious virions compared with a less pathogenic virus in cell culture, Theoretical Biology and Medical Modelling. 14:9(2017).

Akane Hara

NAME

Akane Hara

Email: hara.akane32a[at]gmail.com
Please convert [at] to @ when you send an email.

CURRENT POSITION

Doctorate course student, Graduate School of Systems Life Sciences, Kyushu University

EDUCATION

  • B.S. Kyushu University, Japan, 2016 (Biology)

RESEARCH INTERESTS

Mathematical modeling of allergen immunotherapy

PUBLICATIONS

[1] A. Hara and Y. Iwasa. When is allergen immunotherapy effective?. Journal of Theoretical Biology. Volume 425, 21 July 2017, Pages 23–42. (2017)

Takaaki Funo

NAME

Takaaki Funo

Email: funo-8va[at]live.jp
Please convert [at] to @ when you send an email.

CURRENT POSITION

Doctorate course student, Graduate School of Systems Life Sciences, Kyushu University

EDUCATION

  • B.S. Kyushu University, Japan, 2016 (Biology)

Kousaku Kitagawa

NAME

Kousaku Kitagawa

Email: sack7844[at]gmail.com
Please convert [at] to @ when you send an email.

CURRENT POSITION

Doctorate course student, Graduate School of Systems Life Sciences, Kyushu University

EDUCATION

  • B.S. Kyushu University, Japan, 2017 (Biology)

Tatusya Kurusu

NAME

Tatsuya Kurusu

Email: b.c.kurupon11rm16@gmail.com
Please convert [at] to @ when you send an email.

CURRENT POSITION

Doctorate course student, Graduate School of Systems Life Sciences, Kyushu University

RESEARCH INTERESTS

Modeling HBV entry and quantification an impact of entry inhibition on virus infection with stochastic simulation.

EDUCATION

  • B.S. Kyushu University, Japan, 2017 (Biology)

Kengo Nagata

NAME

Kengo Nagata

Email: grsa777[at]gmail.com
Please convert [at] to @ when you send an email.

CURRENT POSITION

Doctorate course student, Graduate School of Systems Life Sciences, Kyushu University

EDUCATION

  • B.S. Kyushu University, Japan, 2017 (Biology)

Junnosuke Horita

NAME

Junnosuke Horita

Email: 1SC13282K@s.kyushu-u.ac.jp
Please convert [at] to @ when you send an email.

CURRENT POSITION

Doctorate course student, Graduate School of Systems Life Sciences, Kyushu University

EDUCATION

  • B.S. Kyushu University, Japan, 2017 (Biology)

to top