Mathematical Biology Laboratory Department of Biology, Kyushu University


Hiroshi Haeno


Hiroshi Haeno

Email: haeno[at]
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Assistant Professor, Mathematical Biology Laboratory
Department of Biology, Kyushu University


  • 2005 B.S. - Waseda University
  • 2007 M.S. - Kyushu University)
  • 2010 Ph.D (Mathematical Biology) - Kyushu University, Japan


  • 2010 - 2012 Postdoctoral Research Fellow, Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston
  • 2008 - 2010 Research Fellowship of the Japan Society for the Promotion of Science for Young Scientists


Cancer is a major cause of deaths today. There have been tremendous efforts to fight against cancer in vast research field such as molecular biology, cell biology, systems biology, drug discovery, clinical research, and so forth. I am working on mathematical and computational modeling of cancer initiation/progression and optimal treatment. I would like to make it clear the fundamental dynamics of the emergence and the progression of cancer cells as well as the appearance of drug resistance by using mathematical models, which I hope could bring something new to experimental and clinical researchers at the leading edge.


[10] Yamamoto KN, Hirota K, Takeda S, Haeno H. (2014) Evolution of Pre-Existing versus Acquired Resistance to Platinum Drugs and PARP Inhibitors in BRCA-Associated Cancers. PLoS One, 9(8):e105724
[9] Hiroshi Haeno, Yosef E. Maruvka, Yoh Iwasa, and Franziska Michor. Stochastic tunneling of two mutations in a population of cancer cells. PLoS One, 8(6):e65724.
[8] Iwami S*, Haeno H*, Michor F. (2012) (*co-first authors). A race between tumor immunoescape and genome maintenance selects for optimum levels of (epi)genetic instability. PLoS Comput Biol 8(2):e1002370.
[7] Haeno H*, Gonen M*, Davis MB, Herman JM, Iacobuzio-Donahue CA, Michor F. (2012) (*co-first authors). Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies. Cell 148(1-2):362-75.
[6] Hambardzumyan D*, Cheng YK*, Haeno H*, Holland EC, Michor F. (2011) (*co-first authors). The Probable Cell of Origin of NF1-and PDGF-Driven Glioblastomas. PLoS One 6(9):e24454.
[5] Klinakis A, Lobry C, Abdel-Wahab O, Oh P, Haeno H, Buonamici S, van De Walle I, Cathelin S, Trimarchi T, Araldi E, Liu C, Ibrahim S, Beran M, Zavadil J, Efstratiadis A, Taghon T, Michor F, Levine RL, Aifantis I. (2011). A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature 473, 230-3.
[4] Haeno H, F. Michor (2009). The evolution of tumor metastases during clonal expansion. J Theor Biol 263, 30-44.
[3] Haeno H, R. L. Levine, D. G. Gilliland, F. Michor (2009). A progenitor cell origin of myeloid malignancies. Proc Natl Acad Sci USA 106, 16616-16621.
[2] Haeno H, Y. Iwasa, F. Michor (2007). The evolution of two mutations during clonal expansion. Genetics 177, 2209-2221.
[1] Haeno H, Y. Iwasa (2007). Probability of resistance evolution for exponentially growing virus in the host. J Theor Biol 246, 323-331.

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