九州大学数理生物学研究室

李 貞憲(り じょんふぉん)

李 貞憲(り じょんふぉん)

所属:九州大学理学研究院生物科学部門数理生物学研究室

役職:特任助教

所属学会:日本生態学会、日本数理生物学会

連絡先:clinamen2013[at]gmail.com
          traum98[at]bio-math10.biology.kyushu-u.ac.jp
※[at]を@に置き換えて下さい。

略歴

2007年 2月 ソウル国立大学 環境大学院 卒業
2010年 4月〜 九州大学大学院システム生命科学府 数理生物学研究室

研究内容

My research interest is related to environmental problem, biodiversity conservation, poverty, conflicts between people and its resolution. Although those seem different, from the perspective that we can somehow control or at least alleviate suffering from those problems based on our decision to allocate or use our resource, they are connected, so that my academic interest is resource management or allocation, so called, sustainable science. I use very simple dynamics of ecology and human decision until recently which is useful for synchronization of two aspects. The projects I have studied are (1) the resource management of common fishing ground including the possible conflicts which can be caused by new resource usage, (2) optimal allocation of funds for biodiversity between awareness-raising activities of people about biodiversity and direct conservation activities, (3) the optimal level of punishment the role of which has been intensely discussed but the mechanism to decide the level has not yet studied that much despite its importance.

業績

(7) Agent-based mapping of credit risk for sustainable microfinance, PLOS ONE, in press, (2015), Joung-Hun Lee. M. Jusup, B. Podobnik, Y. Iwasa.
(6) Coupled social and ecological dynamics of herders in Mongolian rangelands, Ecological Economics (2015), 114: 208-217. Joung-Hun Lee, K. Kakinuma, T. Okuro, Y. Iwasa.
(5) Games of corruption: How to suppress illegal logging, Journal of Theoretical Biology (2015), 367:1-13. Joung-Hun Lee, K. Sigmund, U. Dieckmann, Y. Iwasa.
(4) Modeling socio-economic aspects of ecosystem management and biodiversity conservation. Population Ecology (2014), 56: 27-40. Joung Hun Lee and Yoh Iwasa.
(3) Graduated punishment is efficient in resource management if people are heterogeneous. Journal of Theoretical Biology (2013), 333: 117-125, Yoh Iwasa and Joung Hun Lee.
(2) Optimal investment for enhancing social concern about biodiversity conservation: A dynamic approach, Theoretical Population Biology (2012), 82: 177-186. Joung Hun Lee and Yoh Iwasa
(1) J.H. Lee and Y. Iwasa. Tourists and traditional divers in a common fishing ground, Ecological Economics. 70(12): 2350-2360 (2011).

太田 加代子(おおた かよこ)

太田 加代子(おおた かよこ)

所属:九州大学理学研究院生物科学部門数理生物学研究室

役職:テクニカルスタッフ

業績

(3) Chakraborty T, Mohapatra S, Tobayama M, Ohta Ka, Ryu YM, Kazeto Y, Ohta Ko, Zhou L, Nagahama Y, Matsubara T, Hatching enzymes disrupt aberrant gonadal degeneration by the autophagy/apoptosis cell fate decision. Sci Rep. 2017, 7(1):3183
(2) Kurta (Ohta) K, Burgess SM, Sakai N. Transgenic zebrafish produced by retroviral infection of in vitro-cultured sperm. PNAS 2004, 101(5): 1263-7
(1) Kurta (Ohta) K, Sakai N. Functionally distinctive testicular cell lines of zebrafish to support male germ cell development. Mol Reprod Dev. 2004, 67(4): 430-8

岩本 将士(いわもと まさし)

所属:九州大学理学研究院生物科学部門数理生物学研究室

役職:特任助教

所属学会:日本ウィルス学会

連絡先:miwamoto[at]nih.go.jp
※[at]を@に置き換えて下さい。

略歴

学歴

2018年3月 東京理科大学大学院 応用生物科学専攻 理学博士 取得

職歴

2015年 4月 - 2018年 3月 日本学術振興会特別研究員DC1
2018年4月-現在 九州大学 大学院理学研究院 生物科学部門 数理生物学研究室 特任助教

業績

(10) Iwamoto M, Cai D, Sugiyama M, Suzuki R, Aizaki H, Ryo A, Ohtani N, Tanaka Y, Mizokami M, Wakita T, Guo H, Watashi K: Functional association of cellular microtubules with viral capsid assembly supports efficient hepatitis B virus replication. Sci. Rep. 7(1): 10620 (2017).
(9) Shimura S, Watashi K, Fukano K, Peel M, Sluder A, Kawai F, Iwamoto M, Tsukuda S, Takeuchi S J, Miyake T, Sugiyama M, Ogasawara Y, Park SY, Tanaka Y, Kusuhara H, Mizokami M, Sureau C, Wakita T: Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity. J Hepatol. 66: 685-692 (2017)
(8) Tsukuda S, Watashi K, Hojima T, Isogawa M, Iwamoto M, Omagari K, Suzuki R, Aizaki H, Kojima S, Sugiyama M, Saito A, Tanaka Y, Mizokami M, Sureau C, Wakita T: A new class of hepatitis B and D virus entry inhibitors, proanthocyanidin and its analogs, that directly act on the viral large surface proteins. Hepatology, 65: 1104-1116 (2017)
(7) Kaneko S, Kakinuma S, AsahinaY, Kamiya A, Miyoshi M, Tsunoda T, Nitta S, Asano Y, Nagata H, Otani S, Kawai-Kitahata F, Murakawa M, Itsui Y, Nakagawa M, Azuma S, Nakauchi H, Nishitsuji H, Ujino S, Shimotohno K, Iwamoto M, Watashi K, Wakita T,& Watanabe M:Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus. Sci. Rep. 6: 29358 (2016).
(6) Nishikori S, Takemoto K, Kamisuki S, Nakajima S, Kuramochi K, Tsukuda S, Iwamoto M, Katayama Y, Suzuki T, Kobayashi S, Watashi K, Sugawara F: Anti-hepatitis C Virus Natural Product from a Fungus, Penicillium herquei. J Nat Prod. 79: 442-6 (2016)
(5) Kaneko M, Watashi K, Kamisuki S, Matsunaga H, Iwamoto M, Kawai F, Ohashi H,  Tsukuda S, Shimura S, Suzuki R, Aizaki H, Sugiyama M, Park SY, Ito T, Ohtani N, Sugawara F, Tanaka Y, Mizokami M, Sureau C, Wakita T: A novel tricyclic polyketide, vanitaracin A, specifically inhibits the entry of hepatitis B and D viruses through targeting NTCP. J Virol. 89: 11945-53 (2015)
(4) Tsukuda S, Watashi K, Iwamoto M, Suzuki R, Aizaki H, Okada M, Sugiyama M, Kojima S, Tanaka Y, Mizokami M, Li J, Tong S, Wakita T.: Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression. J Biol Chem. 290: 5673-5684 (2015)
(3) Watashi K, Sluder A, Daito T, Matsunaga S, Ryo A, Nagamori S, Iwamoto M, Nakajima S, Tsukuda S, Borroto-Esoda K, Sugiyama M, Tanaka Y, Kanai Y, Kusuhara H, Mizokami M, Wakita T.: Cyclosporin A and its analogs inhibit hepatitis B virus entry into cultured hepatocytes through targeting a membrane transporter NTCP. Hepatology, 59: 1726-1737 (2014)
(2) Iwamoto M, Watashi K, Tsukuda S, Aly HH, Fukasawa M, Fujimoto A, Suzuki R, Aizaki H, Ito T, Koiwai O, Kusuhara H, Wakita T.: Evaluation and identification of hepatitis B virus entry inhibitors using HepG2 cells overexpressing a membrane transporter NTCP. Biochem Biophys Res Commun. 443: 808-813 (2014)
(1) Watashi K, Liang G, Iwamoto M, Marusawa H, Uchida N, Daito T, Kitamura K, Muramatsu M, Ohashi H, Kiyohara T, Suzuki R, Li J, Tong S, Tanaka Y, Murata K, Aizaki H, Wakita T.: Interleukin-1 and Tumor Necrosis Factor-α Trigger Restriction of Hepatitis B Virus Infection via a Cytidine Deaminase Activation-induced Cytidine Deaminase (AID). J Biol Chem. 288: 31715-31727 (2013)

総説・著書

(2) Tsukuda S+, Iwamoto M+, Koichi Watashi : NTCP (sodium taurocholate cotransporting polypeptides). Encyclopedia of Signaling Molecules, 2nd Edition (2017). (+equally contribution)
(1) 1) Iwamoto M and Watashi K: Closing the door on hepatitis B and D virus entry: what are our therapeutic options? . Future Virol. 11 (11): 715-718 (2016).

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